Healthy Skepticism Library item: 6733

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Publication type: Journal Article

Applegate WB, Furberg CD, Byington RP, Grimm R Jr.
The Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS)
JAMA 1997 Jan 22-29; 277:(4):297

Abstract:

The undersigned authors participated in the conduct of MIDAS. For the record, we feel it important to state publicly why we dropped out of the investigative group while the final paper was under preparation. At the point of our departure, we believed that the sponsor of the study was attempting to wield undue influence on the nature of the final paper. This effort was so oppressive that we felt it inhibited academic freedom and led to substantial differences within the MIDAS group with regard to the ultimate presentation and interpretation of the results. Fortunately, the published article is very near to the paper we would have written had we remained part of the investigative group. We congratulate the authors on the final product and wish to express our respect for the peer review process that helped lead to an improved publication. [full text]

Keywords:
*letter to the editor/United States/ Antihypertensive Agents/therapeutic use Arteriosclerosis/drug therapy Clinical Trials* Diuretics/therapeutic use Humans Isradipine/therapeutic use Peer Review Publishing*