Healthy Skepticism Library item: 4945
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Publication type: Journal Article
Small DH.
Acetylcholinesterase inhibitors for the treatment of dementia in Alzheimer's disease: do we need new inhibitors?
Expert Opin Emerg Drugs 2005 Nov 01; 10:(4):817-25
http://www.ncbi.nlm.nih.gov/pubmed/16262564
Abstract:
Acetylcholinesterase inhibitors (AChEIs) have been shown to produce a small, but significant, improvement in cognition in patients with Alzheimer’s disease. However, not all patients respond equally, and cognitive benefit may be of limited duration. Although new AChEIs continue to be developed, more recent studies have been aimed at developing inhibitors that have additional actions separate from AChE inhibition. Importantly, new treatments that target the underlying pathogenic mechanism of Alzheimer’s disease (statins, secretase inhibitors, vaccination) may eventually emerge. These new treatments could make AChEI therapy less relevant for treatment of Alzheimer’s disease
Keywords:
Alzheimer Disease/drug therapy*
Alzheimer Disease/enzymology*
Animals
Cholinesterase Inhibitors/chemistry
Cholinesterase Inhibitors/therapeutic use*
Clinical Trials/statistics & numerical data
Clinical Trials/trends
Dementia/drug therapy
Dementia/enzymology
Drug Industry/trends
Drugs, Investigational/chemistry
Drugs, Investigational/therapeutic use*
Humans