Healthy Skepticism Library item: 14899

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: Journal Article

Lexchin J
Clinical trials in Canada: whose interests are paramount?
Int J Health Serv 2008; 38:(3):525-42
http://www.ncbi.nlm.nih.gov/pubmed/18724580

Abstract:

More than 80 percent of clinical drug trials in Canada are funded by the pharmaceutical industry. This article evaluates the overall state of clinical trials in Canada and looks at the interplay between public and private interests. Health Canada has adopted standards developed by the International Conference on Harmonization, a body that is heavily influenced by industry. Commercial interests are increasingly involved in recruiting patients into clinical trials and in running these trials. It is in industry’s interests to conduct drug tests on people for which it is easiest to see benefits. These interests are not fundamentally challenged by Health Canada’s policy of issuing nonmandatory guidelines on who should and should not be included in clinical trials. The outcome of clinical trials is heavily influenced by commercial sponsorship, with the result that trials may favor corporate interests rather than the interests of the public. How Health Canada deals with that possibility is not known, because of its strict policy of treating clinical trial data as private property. If clinical trials are to serve the purpose for which they are designed, developing reliable and objective information about new drugs, then commercial interests cannot be allowed to take precedence over health interests.

Keywords:
Canada Clinical Trials as Topic/ethics* Conflict of Interest* Drug Approval Drug Industry/ethics* Ethics, Research* Humans Patient Selection/ethics Research Support as Topic/ethics*