Healthy Skepticism International News
Servier Arcalion (sulbutiamine) and Duxaril (almitrine/raubasine)
May 1995
Vol 13 Issue 5 This month: Servier's promotion of Arcalion (sulbutiamine) and Duxaril (almitrine/raubasine) in the Philippines. Claims of "proven efficacy in all forms of asthenia" for sulbutiamine. Almitrine/raubasine said to be "the first drug to improve cerebral arterial oxygen content" and to provide "major benefits in cerebral symptoms, in visual symptoms, in ENT symptoms" but nothing is said about the possible occurence of severe adverse effects including peripheral neurological disorders. News: Follow-up on our June 1994 letter to Hoechst. Hoechst will discontinue Baralgin (dipyrone/pitofenone/fenpiverinium) in the Philippines as it is unable to prove the efficacy of the combination product using modern techniques. Dipyrone remains as a single agent despite unresolved safety questions.
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