May/June 1999 Vol 17 No 5/6 ISSN 1321-571X
Boehringer Ingelheim promotes Atrovent (ipratropium bromide)
in Russia as first
line for chronic bronchitis.
A request from Russia
On 9 December 1998 we received the
following e-mail from Russia:
Dear Peter,
In Russia long time Boehringer Ingelheim advertise Atrovent (ipratropium
bromide) using the chess board image and question: 'Chronic bronchitis:
your first step? e2-e4 Atrovent'.
I think that it is not correct advertisement, Atrovent is not the agent of
first choice for the initial treatment of all types of chronic bronchitis.
Is it good target for MALAM action?
vasya
Vasiliy Vlassov Dr. Med. Sci., Professor
Saratov State Medical University
A copy of the
advertisement for Atrovent in Russia appears below.
Pharmaceutical marketing in Russia
In 1997 the
Russian pharmaceutical market was one of the fastest growing markets in the
world and reached US$ 3.5 billion. That
was 25% more than the previous year.<1>
This rapid growth rate may reflect increased use of promotion to doctors who are not accustomed to it.
In August
1998 the Russian economy crashed.
Responses from drug companies have varied. For example:
“Eli
Lilly have continued to distribute life saving pharmaceuticals, such as
insulin, despite non-payments from distributors.”
but
“Smith
Kline Beecham increased it budget for advertising and promotion of its
products, increased prices, and declared no intention to withdraw from Russia.” <1>
Boehringer Ingelheim
According to
Boehringer Ingelheim’s web site the company ranks among the top 20 pharmaceutical companies in the world. It reported revenues
exceeding DM 8.75 billion in 1998.
Boehringer
Ingelheim’s “Vision statement on Value” is interesting regardless of whether or
not the company’s staff take it seriously:
“Value
will be our competitive advantage, our customers demand more for less.
Our
customers are objective, professional and analytical. They have a balanced view
of purchasing. The value of our customers' demands is changing and will
continue to change. We need to anticipate the value our customers will place on
our products and services now and in the future. We will only be able to exceed
our customers' expectations by being closer to them. We have to share their
values, aspirations and problems. We need to understand how they use our
products, how we can make our products more efficient and effective, and how
our products answer the needs of our customers. The closer we all are to our
customers, the easier it will be. We have to remove the barriers between them
and us and between ourselves. We have to be one group with a shared objective.”
1. Undated
Advertisement. Scrip Industry Alert. The Russian Pharmaceutical Market: What
next? London, Scrip Reports 1999

Dr Heribert
Johann
Chairman of
the Board
Boehringer
Ingelheim GmbH
Binger Strasse 173
D-55216 Ingelheim am Rhein
GERMANY
re: the promotion of Atrovent (ipratropium bromide)
Professor
Vasily Vlassov of the
Saratov State Medical University, Russia, has
asked MaLAM <1> to write to you about an advertisement for Atrovent
(ipratropium bromide) published in his country. The advertisement uses the image of a chess game and some small
but very active dancers and asserts:
“Chronic
bronchitis:
your first step?
e2-e4
Atrovent”
We understand from
Professor Vlassov that Russian doctors are likely to take away from that
advertisement the message that Atrovent alone is always the best choice for the
initial treatment of all types of chronic bronchitis. We are also concerned that the image of tiny dancers in the
advertisement may lead to an association (perhaps subconsciously) between
Atrovent and dramatic improvement so that patients gain the capacity for
vigorous physical activity. The
advertisement fails to provide any safety information. Consequently the advertisement could lead
doctors to believe that Atrovent may be used by all types of patients without
any safety concerns.
Question
1: Are those the messages that your
company intends to send?
Question
2: What is your best evidence to
support those messages that are intended?
Question
3: What steps will be taken to ensure
that unintended messages are not sent in the future?
Comparison of those
messages with initial conclusions based on the expert opinion available to
MaLAM, summarised below, raises some questions. This letter is intended to give you the opportunity to express
your point of view so that we can assess whether or not your promotion of
Atrovent assists appropriate therapy.
We hope that you will either provide evidence to support your
advertisement or reconsider the way you promote Atrovent. We are
optimistic that dialogue can lead to improvements in drug promotion to the
benefit of the public, health professionals and your company in accord with
your company’s “Vision statement on Value”.<2>
Initial conclusions from expert
opinion.
The first step in therapy for chronic
bronchitis is avoidance of causative factors such as smoke dust and fumes.
Assistance with overcoming nicotine addiction is the only intervention that has
been shown to slow progression of chronic bronchitis.<3>
“Used alone [Atrovent] is not a powerful
bronchodilator. However its effects are
additive to those of commonly used doses of b2-adrenoceptor agonists, so it is
usually used in conjunction with b2-adrenoceptor agonist therapy.”<4>
Atrovent may provide a
modest benefit for patients who have continuous symptoms. However, for patients with intermittent
symptoms the 1998 guidelines from the Canadian Respiratory Review Panel
recommend using a beta-2 agonist without Atrovent.<5> If there is increased cough and dyspnoea
together with increased sputum volume and/or purulence then antibacterials (eg
amoxycillin or doxycycline) may be beneficial.<6> For very severe exacerbations intravenous
corticosteriods are recommended.<4>
While Atrovent may be
better than placebo, it rarely restores respiratory function to normal
values. Furthermore there are many
patients for whom Atrovent provides no clinically important
benefit.<7>
Atrovent is generally
considered to be a safe drug but experience with pregnant and lactating women
is limited. On rare occasions Atrovent
may cause urinary retention and acute angle closure glaucoma <3> and
therefore should be used with caution in patients with or at risk of either of
those two conditions.
Additional
questions
Question 4:
Does your company believe that advertisements for drugs should include
safety warnings?
Question 5: What methods does your
company have for monitoring the quality of promotion by subsidiaries?
Dr Joel Lexchin MD, CCFP
(EM), DABEM
Secretary, MaLAM Inc
www.camtech.net.au/malam
1.
1.
Mansfield PR.
MaLAM, a medical lobby for appropriate marketing of pharmaceuticals. Med J Aust
1997;167:590-592
2.
2.
Barlow J, Møller C.
A complaint is a gift: using customer feedback as a strategic tool.
Berrett-Koehler San Francisco 1996
3.
3.
Australian
Medicines Handbook. Adelaide: AMH Ltd. 1998
4.
4.
Respiratory
Drug Guidelines Sub-Committee. Respiratory Drug Guidelines, 1st
edition. Melbourne: Therapeutic Guidelines Ltd, 1994.
5.
5.
Canadian
Respiratory Review Panel. Guidelines for the treatment of chronic obstructive
pulmonary disease (COPD). Toronto: Medication Use Management Guidelines
Clearinghouse, 1998.
6.
6.
Antibiotic
Guidelines Sub-Committee. Therapeutic Guidelines: Antibiotic, 10th
edition. Melbourne: Therapeutic Guidelines Ltd, 1998.
7.
7.
Ariano
R, Giacca S. Variations of individual susceptibility to beta-adrenergic and
anticholinergic bronchodilator drugs. Minerva Pneumol 1981;20:3:141-147
Dr Heribert
Johann
Chairman of
the Board
Boehringer
Ingelheim GmbH
Binger Strasse 173
D-55216 Ingelheim am Rhein
GERMANY
re: the promotion of Atrovent (ipratropium bromide)
I have read the MaLAM International edition
about the promotion of Atrovent by your company in Russia.
(Please tick where appropriate)
I am a: doctor
pharmacist
nurse
………………………..
and would appreciate receiving a personal copy
of your reply.
Yours sincerely,