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Healthy Skepticism Library item: 16869

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: Journal Article

Tfelt-Hansen PC
Unpublished clinical trials with sumatriptan
The Lancet 2009 Oct 31; 374:(9700):1501 - 1502
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61906-1/fulltext


Abstract:

In 1991, the first triptan, sumatriptan, became available in Europe for the treatment of acute migraine attacks. In 1994—95, a randomised clinical trial (RCT) of sumatriptan 25 mg suppositories versus Cafergot (ergotamine 2 mg plus caffeine 200 mg) suppositories was done in France and Germany. I became aware of this RCT in 1998 when the main result was published on the homepage of the Swedish Medical Agency. I included the finding, that Cafergot resulted in headache relief (a decrease from moder …

 

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"Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made."
- William Osler 1909