Healthy Skepticism Library item: 16869

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Publication type: Journal Article

Tfelt-Hansen PC
Unpublished clinical trials with sumatriptan
The Lancet 2009 Oct 31; 374:(9700):1501 - 1502
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61906-1/fulltext

Abstract:

In 1991, the first triptan, sumatriptan, became available in Europe for the treatment of acute migraine attacks. In 1994-95, a randomised clinical trial (RCT) of sumatriptan 25 mg suppositories versus Cafergot (ergotamine 2 mg plus caffeine 200 mg) suppositories was done in France and Germany. I became aware of this RCT in 1998 when the main result was published on the homepage of the Swedish Medical Agency. I included the finding, that Cafergot resulted in headache relief (a decrease from moder …