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Healthy Skepticism Announcements

Independent drug bulletin: Prescrire International now available in English in 11 issues per year

Prescrire is a non-profit, continuing education organisation that is completely independent of any ties to government or industry. Prescrire's managers and editorial staff sign a yearly statement certifying that they have no conflicts of interest. Prescrire's publications accept no advertising, grants or other outside support or any kind.

Visit: http://english.prescrire.org/en/

 

Prescrire International is totally funded by subscribers, with no support from the pharmaceutical industry or government. It is monthly and published 11 times a year as of November 2010.

Health professionals in low-income countries (excluding drug companies) can benefit from a subscription to Prescrire International thanks to Solidarity Subscription Rates.

Contents of the December issue include:

EDITORIAL
=========

Cherry-picking
Beware selective excerpts from the SPC
FREE

NEW PRODUCTS
============

Timothy pollen (hay fever) (A Second Look)
Longer follow-up, but still no proven advantage

INN common stems: -onidine, -arotene

Temsirolimus (mantle cell lymphoma) (New Indication)
Highly toxic, limited efficacy

Ivabradine (stable angina) (New Indication)
Do not use instead of, or with, a beta-blocker

Certolizumab pegol (rheumatoid arthritis) (New Drug)
Just another TNF alpha antagonist, no therapeutic advantage

Duloxetine (Labelling Change)
Also avoid its use in recurrent depression

ADVERSE EFFECTS
===============
Tibolone and breast cancer
Evidence of increased risk
FREE

Routine antibiotics for preterm labour: risk of cerebral palsy
Do not use in women without membrane rupture or infection

Finasteride: male breast cancer
British data

Desmopressin: more cases of water intoxication
A French pharmacovigilance survey

REVIEWS
=======
Acute poisoning following ingestion of medicines: initial management

Paracetamol poisoning: acetylcysteine to protect the liver

Preventing absorption of ingested toxins

Opioids and naloxone

Emergency drugs for acute medication poisoning

OUTLOOK
=======
Clinical data revealed in court
Hidden by drug companies, withheld by Food and Drug Administration

Who funds patient groups?
French diabetes patient group unhappy with Prescrire

 

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As an advertising man, I can assure you that advertising which does not work does not continue to run. If experience did not show beyond doubt that the great majority of doctors are splendidly responsive to current [prescription drug] advertising, new techniques would be devised in short order. And if, indeed, candor, accuracy, scientific completeness, and a permanent ban on cartoons came to be essential for the successful promotion of [prescription] drugs, advertising would have no choice but to comply.
- Pierre R. Garai (advertising executive) 1963